The Transformative Education for Sustainable Social Impact (TESSI) Institute is a one-week interdisciplinary workshop designed to empower faculty with the expertise and tools needed to reshape their courses and curricula in response to global grand challenges. Rooted in the principles of creative inquiry and the praxis of Humanitarian Engineering and Social Entrepreneurship, the TESSI Institute offers educators an innovative framework for crafting curricula that engage students in authentic, real-world projects, where they co-create innovative, practical, and sustainable solutions that address the needs of vulnerable populations and communities facing social, economic, and environmental challenges.